NF-κB and AP-1 dual inhibitor
SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160801 |
| Réf. fabricant | 18753419 |
| Nom chimique ou matériau | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| CAS | 154563-54-9 |
| Quantité | 10 mg |
| Cible | NFkB/IkB Inhibitors |
| Formule moléculaire | C<sub>14</sub>H<sub>5</sub>ClF<sub>9</sub>N<sub>3</sub>O |
| Poids de la formule | 437.65 |
| Pureté | >99% |
