Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160813 |
| Réf. fabricant | 18796185 |
| Nom chimique ou matériau | Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate |
| CAS | 2400954-58-5 |
| Quantité | 2 mg |
| Cible | STING/TMEM173 |
| Formule moléculaire | C<sub>11</sub>H<sub>8</sub>F<sub>2</sub>IN<sub>5</sub>O<sub>2</sub> |
| Pureté | 0.98 |
