CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.
- Nom chimique ou matériau
- 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
- CAS
- 68003-38-3
- Quantité
- 10 mg
- Cible
- Other Ion Pump/Transporter Inhibitors
- Formule moléculaire
- C13H9ClN2O6S
- Pureté
- 98%
