Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
- Nom chimique ou matériau
- 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
- CAS
- 252979-56-9
- Plage de pourcentage du dosage
- >98%
- Quantité
- 25 mg
- Formule moléculaire
- C22H28N4O6.2HCl
- Poids de la formule
- Observed MW: 517.4
