Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy
in vivo
when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-160844 |
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| Réf. fabricant | 18706416 |
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| Nom chimique ou matériau | 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride |
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| CAS | 252979-56-9 |
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| Plage de pourcentage du dosage | >98% |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>22</sub>H<sub>28</sub>N<sub>4</sub>O<sub>6</sub>.2HCl |
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| Poids de la formule | Observed MW: 517.4 |
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