Potent covalent inhibitor of Cereblon
EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO2F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160880 |
| Réf. fabricant | 30000420 |
| Nom chimique ou matériau | 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride |
| CAS | 2803819-61-4 |
| Quantité | 10 mg |
| Cible | CRBN |
| Formule moléculaire | C<sub>13</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>5</sub>S |
| Pureté | 95% |
