Tocris Bioscience™ EM12-SO2F

Ref : 30000420
150.10

Potent covalent inhibitor of Cereblon

Nom chimique ou matériau :
2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
CAS :
2803819-61-4
Quantité :
10 mg
Cible :
CRBN
Formule moléculaire :
C13H11FN2O5S
Pureté :
95%
Brand
Tocris Bioscience™
EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO2F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

Nom chimique ou matériau : 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride

CAS : 2803819-61-4

Quantité : 10 mg

Cible : CRBN

Formule moléculaire : C13H11FN2O5S

Pureté : 95%

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