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STEMCELL Technologies Wortmannin

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Ref: 17160242

113.40€ - 363.15€

PI3K/AKT pathway inhibitor; Inhibits PI3K and PLKs

CAS:

19545-26-7

Synonyme:

KY 12420

Quantité:

1 mg

Formule moléculaire:

C23H24O8

Pureté:

≥98%

Brand

STEMCELL Technologies

Wortmannin is a fungal metabolite that covalently binds to and inhibits phosphatidylinositol-3-kinases (PI3K) of class I, II, and III
Species-specific differences in the class II PI3Ks determine sensitivity with IC₅₀ = 5, 50, and 450 nM for Drosophila, mouse, and human, respectively (Fruman et al.; Wymann et al.; Okada et al.) Wortmannin also inhibits polo-like kinases (PLK) PLK1 and PLK3 with IC₅₀ = 24 and 49 nM, respectively (Liu et al. 2005; Liu et al. 2007)
At high concentrations it can also inhibit other kinases such as mammalian target of rapamycin (mTOR), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), phosphatidylinositol-4-kinase (PI4K), myosin light-chain kinase (MLCK), and mitogen-activated protein kinase (MAPK; Fruman et al.; Meyers & Cantley; Hartley et al.; Brunn et al.; Nakanishi et al.)

CAS : 19545-26-7

Synonyme : KY 12420

Quantité : 1 mg

Formule moléculaire : C₂₃H₂₄O₈

Pureté : ≥98%

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