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STEMCELL Technologies PLX4032

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Ref: 17190202

sur devis - 310.50€

MEK/ERK pathway inhibitor; Inhibits B-RAF

CAS:

918504-65-1

Synonyme:

RG-7204; Ro 51-85426; Vemurafenib; Zelboraf™

Quantité:

50 mg

Formule moléculaire:

C23H18ClF2N3O3S

Pureté:

≥98%

Brand

STEMCELL Technologies

PLX4032 is an ATP-competitive inhibitor of the serine/threonine kinase B-RAF proto-oncogene, with IC₅₀ values of 31 and 100 nM for the wild-type and V600E mutant forms respectively (Khazak et al.; Sala et al.)
Inhibits proliferation in colon, melanoma, and thyroid carcinoma cancer cell lines expressing B-RAF V600E, alone or in synergy with taxol, vinblastine, and oxaliplatin compounds (Khazak et al.)
Suppresses MEK and ERK phosphorylation downstream of B-RAF in melanoma cells with mutations at the V600 position, correlated with antiproliferative effects (Joseph et al.; Yang et al.)
Inhibits tumor growth in B-RAF V600E melanoma tumor xenograft models (Yang et al.)

CAS : 918504-65-1

Synonyme : RG-7204; Ro 51-85426; Vemurafenib; Zelboraf™

Quantité : 50 mg

Formule moléculaire : C₂₃H₁₈ClF₂N₃O₃S

Pureté : ≥98%

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