Selective antagonist of Mfn1-βIIPKC association
TAT-SAMβA Peptide is a selective antagonist of Mfn1-βIIPKC association. Comprises the cell permeable peptide TAT47-57, conjugated to βIIPKC624-632 by a Gly-Gly spacer. TAT-SAMβA Peptide reduces mitochondrial fragmentation and stress-induced death in cultured cardiomyocytes. In rats with heart failure, TAT-SAMβA Peptide restores mitochondrial morphology, bioenergetics, and redox balance, which leads to improvement in cardiac contractility.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-162401 |
| Réf. fabricant | 18745795 |
| Quantité | 1 mg |
| Cible | Mitofusin 1 |
| Formule moléculaire | C<sub>118</sub>H<sub>195</sub>N<sub>51</sub>O<sub>31</sub> |
| Pureté | 0.95 |
