Potent TRPV4 agonist
GSK 1016790A is a potent TRPV4 agonist; elicits Ca2+ influx in human and mouse TRPV4-expressing HEK cells (EC50 values of 2.1 and 18 nM, respectively). Enhances insulin mRNA expression. Increases ERK1/2 phosphorylation and NO production. Exhibits no activity at TRPM8 and TRPA1 (20 μM) channels. Induces bladder overactivity in TRPV4+/+ mice.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-162417 |
| Réf. fabricant | 18739966 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>28</sub>H<sub>32</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>6</sub>S<sub>2</sub> |
| Poids de la formule | 655.61 |
| Type de produit | Agonist |
| Pureté | 98% |
