"/> Tocris Bioscience™ HHP 9 | B-LABO France

Tocris Bioscience™ HHP 9

Name: Tocris Bioscience™ HHP 9
Brand: Tocris Bioscience
SKU: 30000664
Price: 348.80 EUR
Availability: InStock

Réf. : BL-RE-164975Réf. fabricant : 30000664 5 mg

348,80 € HT

BET bromodomain Degrader (PROTAC™); also potent Hedgehog pathway inhibitor

Nom chimique ou matériau: 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Quantité: 5 mg
Cible: Active Degraders
Formule moléculaire: C₄₉H₅₂N₆O₁₁
Pureté: 0.98
Marque: Tocris Bioscience

HHP 9 is a potent BET bromodomain Degrader (PROTAC™; DC50 values are 0.03 μM, 0.2 μM and 0.2 μM at BRD3, BRD2 and BRD4 respectively). BRD2, BRD3 and BRD4 are almost completely degraded by HHP 9

in vitro

(after 27h incubation with 0.5 - 5 μM of HHP 9). Comprises a Hedgehog Pathway Inhibitor-1 ( HPI-1, Cat. No. 3839) coupled to a CRBN ligand. BET bromodomain degradation through HPP-9 results in long-acting Hh pathway inhibition.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-164975
Réf. fabricant	30000664
Nom chimique ou matériau	2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Quantité	5 mg
Cible	Active Degraders
Formule moléculaire	C<sub>49</sub>H<sub>52</sub>N<sub>6</sub>O<sub>11</sub>
Pureté	0.98

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Tocris Bioscience™ HHP 9

Caractéristiques techniques

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