ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (Kd = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-164983 |
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| Réf. fabricant | 30042724 |
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| Nom chimique ou matériau | 5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone |
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| CAS | 459789-75-4 |
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| Quantité | 10 mg |
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| Cible | CEACAM1/CD66a |
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| Formule moléculaire | C<sub>27</sub>H<sub>17</sub>Cl<sub>2</sub>NO<sub>5</sub> |
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| Pureté | 0.98 |
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