"/> Tocris Bioscience™ MS 147 | B-LABO France

Tocris Bioscience™ MS 147

Name: Tocris Bioscience™ MS 147
Brand: Tocris Bioscience
SKU: 30067466
Price: 254.85 EUR
Availability: InStock

Réf. : BL-RE-165033Réf. fabricant : 30067466 2 mg

254,85 € HT

PRC1 Degrader (PROTAC™); degrades BMI1 and RING1B

Nom chimique ou matériau: (2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Quantité: 2 mg
Cible: Active Degraders
Formule moléculaire: C₅₄H₇₀N₁₂O₆S.xHCl
Pureté: 0.97
Marque: Tocris Bioscience

MS 147 is a polycomb repressive complex 1 (PRC1) Degrader (PROTAC™) (Kd values are 450 nM and 3 μM for VHL and EED, respectively). Comprises an EED binder ( EED 226, Cat. No. 7762) joined by a linker to a VHL E3 ligase ligand. MS 147 preferentially degrades BMI1 and RING1B and reduces H2AK119ub in K562 cells. Inhibits proliferation in cancer cell lines that are insensitive to EZH2 knockout or EED/PRC2 Degraders.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-165033
Réf. fabricant	30067466
Nom chimique ou matériau	(2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Quantité	2 mg
Cible	Active Degraders
Formule moléculaire	C<sub>54</sub>H<sub>70</sub>N<sub>12</sub>O<sub>6</sub>S.xHCl
Pureté	0.97

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Tocris Bioscience™ MS 147

Caractéristiques techniques

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