Bafilomycin A1 is a potent and selective inhibitor of the vacuolar-type H+-ATPase (V-ATPase), an enzyme responsible for maintaining acidic pH in cellular compartments such as lysosomes and endosomes.
In the life science field, Bafilomycin A1 is primarily used as a research tool to investigate the role of V-ATPase and lysosomal acidification in various cellular processes. By inhibiting V-ATPase, Bafilomycin A1 disrupts the acidification of cellular compartments, which in turn affects processes such as protein degradation, autophagy, endocytosis, and vesicular trafficking.
Bafilomycin A1 can be used to study autophagy, a cellular process involved in the degradation and recycling of cellular components. By inhibiting V-ATPase, Bafilomycin A1 blocks the final step of autophagy, preventing the fusion of autophagosomes with lysosomes and thereby inhibiting autophagic degradation.
| Marque | Melford |
|---|---|
| Réf. B-LABO | BL-RE-165288 |
| Réf. fabricant | 30018083 |
| Nom chimique ou matériau | Bafilomycin A1 |
| CAS | 88899-55-2 |
| Formule moléculaire | C35H58O9 |
| Quantité | 1 mg |
