UH15-38 is a potent and selective receptor interacting protein kinase 3 (RIPK3) inhibitor (IC50 = 20 nM). UH15-38 potently and selectively blocks influenza A-induced necroptosis in alveolar epithelial cells
in vivo
(IC50 = 39.5 nM), and prevents damage from lung inflammation without compromising antiviral adaptive immune responses or impeding viral clearance. Blocks TNFα-induced necroptosis in primary murine embryonic fibroblasts (IC50 = 98 nM) and mouse cell lines
in vitro
Caractéristiques techniques
| Marque | Tocris Bioscience |
|---|
| Réf. B-LABO | BL-RE-165677 |
|---|
| Réf. fabricant | 30000657 |
|---|
| Nom chimique ou matériau | 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride |
|---|
| Quantité | 50 mg |
|---|
| Cible | RIPK3/RIP3 |
|---|
| Formule moléculaire | C<sub>26</sub>H<sub>27</sub>N<sub>5</sub>O<sub>2</sub>.2HCl |
|---|
| Pureté | 0.98 |
|---|
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