Atypical chemokine receptor (ACKR3) agonist
LIH 383 is a potent and highly selective atypical chemokine receptor (ACKR3/CXCR7) agonist. LIH 383 competes directly with CXCL12-AF647 and is more potent in inducing β-arrestin recruitment to ACKR3 (EC50 = 0.61 nM) than the full-length chemokine ligands CXCL12 or CXCL11 (EC50 = 1.2 nM and 2.2 nM, respectively). In a rat
ex vivo
model, LIH383 increases the availability and signaling of opioid peptides at classical receptors.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-166567 |
| Réf. fabricant | 30130458 |
| Pureté | 0.95 |
| CAS | 2866266-58-0 |
| Contenu et stockage | Store at -20°C |
| Poids moléculaire | 997.23 |
| Quantité | 1 mg |
