Ecto-5'-nucleotidase (CD73) inhibitor
Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses doxorubicin -resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor, induces inflammation in a rodent model of pleurisy, and reduces memory loss induced by Aβ1-42 in a mouse model of Alzheimer's disease.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-166589 |
| Réf. fabricant | 30158295 |
| Nom chimique ou matériau | α,β-Methyleneadenosine 5'-diphosphate disodium salt |
| CAS | 104835-70-3 |
| Quantité | 10 mg |
| Cible | 5'-Nucleotidase/CD73 |
| Formule moléculaire | C11H15N5Na2O9P2 |
| Pureté | 0.98 |
