IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
- Numéro d’adhésion
- P22301
- Plage de dosage
- Lot-specific
- Sensibilité du dosage
- Lot-specific
- Conjugué
- HRP
- Type de produit
- ELISA Kit
- À utiliser avec (équipement)
- Colorimetric Microplate Reader
- Identification génétique (Entrez)
- 3586
- Symbole de gène(s)
- IL10
- Contenus des kits
- This Human IL-10 ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately.
- Marqueur ou colorant
- HRP
- Quantité
- 10 x 96 Tests
- État réglementaire
- RUO
- Conditions de stockage
- Refer to product documentation for component specific storage temperature.
- Cible
- Human IL-10 ELISA Development Kit (ABTS)
- Heure du test
- 1 hr 45 min
- Durée totale du dosage
- 24 hr 30 min
