Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
Caractéristiques techniques
| Marque | Invitrogen |
| Réf. B-LABO | BL-RE-167119 |
| Réf. fabricant | 30089207 |
| Numéro d’adhésion | P40225 |
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| Plage de dosage | Lot-specific |
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| Sensibilité du dosage | Lot-specific |
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| Conjugué | HRP |
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| Type de produit | ELISA Kit |
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| À utiliser avec (équipement) | Colorimetric Microplate Reader |
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| Identification génétique (Entrez) | 7066 |
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| Symbole de gène(s) | THPO |
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| Contenus des kits | This Human Thrombopoietin ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately. |
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| Marqueur ou colorant | HRP |
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| Quantité | 10 x 96 Tests |
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| État réglementaire | RUO |
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| Conditions de stockage | Refer to product documentation for component specific storage temperature. |
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| Cible | Human TPO ELISA Development Kit (ABTS) |
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| Heure du test | 1 hr 45 min |
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| Durée totale du dosage | 24 hr 30 min |
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