Spectrum: Rifampicin is a broad-spectrum antibiotic with a wide range of activity including: Gram-positive aerobic bacteria, particularly Staphylococcus spp and Rhodococcus equ. Brucella and some other fastidious organisms are susceptible but Gram-negative bacteria more generally are resistant; Gram-positive and Gram-negative anaerobic bacteria at low concentrations, including Bacteroides fragilis, Chlamydophila and Rickettsia; Mycobacterium tuberculosis (note: most other mycobacteria are resistant); some protozoa; some fungi; and poxviruses
Mechanism of Action: Rifampicin targets prokaryotic DNA-dependent RNA polymerases which prevent subsequent RNA transcription and protein translation. Bacterial resistance to Rifampicin is caused by mutations leading to a change in the structure of the β-subunit of RNA polymerase. Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to the β-subunit of RNA polymerase, which results in cell death. Rifampicin has been shown to inhibit α-synuclein fibrillation and disaggregate fibrils in a concentration-dependent manner. Rifampicin can activate pregnane X receptor (PXR), which affects cytochrome P450, and the activity of glucuronosyltransferases and P-glycoprotein. Rifampicin has been shown to enhance CYP2C-mediated metabolism, affecting compounds that are transported by P-glycoprotein and metabolized by CYP3A4
Caractéristiques techniques
Marque
TOKU-E
Réf. B-LABO
BL-RE-167401
Réf. fabricant
30044020
CAS
13292-46-1
Nom chimique ou matériau
Rifampicin
Couleur
Red
Contenu et stockage
-20°C, Protect from light
Concentration
8 to 12 mg/mL
Forme
Liquid
Type de produit
Antibiotic
Stérilité
Sterile
Sterilization Method
Sterile-filtered
Avec additifs
None
Sans additif
None
Formule
Liquid in Water
À utiliser avec (application)
Microbiology, Plant Biology and Eukaryotic Cell Culture Applications
Gamme de produits
ReadyMade™ Solutions
Pureté ou qualité
>90%
Quantité
100 mL
Conditions d’expédition
Ice Pack
Source
Semi-synthetic
Espèces
Bacteria
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