For the quantitative detection of Human IL-10
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
| Marque | Invitrogen |
|---|---|
| Réf. B-LABO | BL-RE-171980 |
| Réf. fabricant | 18021663 |
| Numéro d’adhésion | P22301 |
| Plage de dosage | 0.39 to 25.0 pg/ml |
| Sensibilité du dosage | 0.03 pg/mL |
| Conjugué | HRP |
| Type de produit | ELISA |
| Type d’échantillon | Plasma |
| À utiliser avec (équipement) | Colorimetric Microplate Reader |
| Identification génétique (Entrez) | 3586 |
| Symbole de gène(s) | IL10 |
| Coefficient de variation inter-dosage | 7.5% |
| Coefficient de variation intra-dosage | 6.8% |
| Contenus des kits | Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, Amplification Reagent I, Amplification Reagent II, SAV-HRP, Controls, Wash Buffer, Chromogen Stop Solution Adhesive Plate Covers |
| Marqueur ou colorant | HRP |
| Quantité | 96 Tests |
| État réglementaire | RUO |
| Volume d’échantillon | 50 µL |
| Conditions de stockage | 2°C to 8°C |
| Cible | Human |
| Heure du test | 1 hr 20 min |
| Durée totale du dosage | 4 hr |
