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Thermo Scientific™ Dynabeads™ CaptureSelect™ AAV9 Magnetic Beads

Réf. : BL-RE-175282Réf. fabricant : 30275957 1 mL
456,00 € HT

Thermo Scientific™ Dynabeads™ CaptureSelect™ AAV9 Magnetic Beads are high-capacity, high-throughput magnetic affinity particles for the purification of naturally occurring and synthetic adeno-associated virus serotype 9 (AAV9) used for gene therapy applications.

Capacité de liaison
>0.5 x 1011 vp/mg beads
Capacité (métrique)
1 mL
Concentration
30 mg beads/mL slurry, 1 mg contains approximately 1.3 x 107 beads
Formule
4 to 6% (v/v) Slurry
Matrice
Non-porous monodisperse superparamagnetic beads
Marque
Thermo Scientific

Dynabeads CaptureSelect AAV9 Magnetic Beads are high-capacity, high-throughput magnetic affinity particles for the purification of naturally occurring and synthetic adeno-associated virus serotype 9 (AAV9) used for gene therapy applications. The anti-AAV9 affinity ligand demonstrates good binding reactivity towards the AAV9 serotype. The magnetic beads enable purification using manual and robotic magnetic separators of the AAV9 serotype directly from crude feedstock in a single step with high purity and yield.

Features of DynaBeads CaptureSelect AAV9 Magnetic Beads include:

The magnetic beads bind with high affinity specifically to the AAV9 serotype. For the isolation of other AAV serotype capsids we recommend DynaBeads CaptureSelect AAVX magnetic beads (Cat. No. 2853522001, 2853522005, 2853522050).

Points forts

Animal origin statement

CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a ∼12–15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain. The ligand is efficiently produced in yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).

Main characteristics

  • Bead matrix: non-porous monodisperse superparamagnetic beads
  • Bead size: 4.5 μm
  • Ligand: CaptureSelect AAV9 affinity ligand
  • Binding capacity: >5 x 1011 viral particles/mg beads
  • Elution conditions: 50 mM citric acid, pH 2.5–3.0
  • Formulation buffer: tris-buffered saline, 0.05% Tween 20, 0.05 % sodium azide

Caractéristiques principales

  • One-magnetic-step AAV purification from crude material with high purity and yield
  • Compatible with manual and automated workflows
  • High specificity and capacity
  • Easy upscaling to higher volumes
  • Non-animal derived

Caractéristiques techniques

MarqueThermo Scientific
Réf. B-LABOBL-RE-175282
Réf. fabricant30275957
Capacité de liaison>0.5 x 10<sup>11</sup> vp/mg beads
Capacité (métrique)1 mL
Concentration30 mg beads/mL slurry, 1 mg contains approximately 1.3 x 10<sup>7</sup> beads
Formule4 to 6% (v/v) Slurry
MatriceNon-porous monodisperse superparamagnetic beads
Granulométrie4.5 μm
Gamme de produitsCaptureSelect™
Quantité1 mL
À utiliser avec (application)Magnetic isolation of AAV9 capsids
CibleAAV9 (Adeno-associated serotype 9)
Type de ligandCaptureSelect™ AAV9 Affinity Ligand
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