Synthetic Peptide
Human LXR Alpha (residues 432-442) Synthetic Peptide, PEP-115, from Invitrogen.
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
| Marque | Invitrogen |
|---|---|
| Réf. B-LABO | BL-RE-175634 |
| Réf. fabricant | 11524770 |
| Gene ID (Entrez) | 10062 |
| Espèces | Human |
| Méthode de purification | purified |
| Numéro d’adhésion | Q13133 |
| Nom usuel | Human LXR alpha (aa 432-442) |
| Concentration | 0.5 mg/mL |
| Contenu et stockage | -20°C. Avoid freeze-thaw cycles. |
| Format | Lyophilized |
| Formule | peptide with no preservative |
| À utiliser avec (application) | Control |
| Symbole de gène(s) | NR1H3 |
| Lyophilisé | Lyophilized |
| Conservateur | No preservative |
| Type de produit | Peptide |
| Quantité | 50 μg |
| État réglementaire | RUO - research use only |
| Séquence | C-L432-R-L-Q-D-K-K-L-P-P-L-L-S-E445 |
