Synthetic Peptide
Human Maxi K+ alpha (residues 887-902) Synthetic Peptide, PEP-122, from Invitrogen.
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
| Marque | Invitrogen |
|---|---|
| Réf. B-LABO | BL-RE-176257 |
| Réf. fabricant | 11594770 |
| Gene ID (Entrez) | 3778 |
| Espèces | Human |
| Méthode de purification | purified |
| Numéro d’adhésion | Q12791 |
| Nom usuel | Human KCNMA1 (aa 887-902) |
| Concentration | 0.5 mg/mL |
| Contenu et stockage | -20°C. Avoid freeze-thaw cycles. |
| Format | Lyophilized |
| Formule | peptide with no preservative |
| À utiliser avec (application) | Control |
| Symbole de gène(s) | KCNMA1 |
| Lyophilisé | Lyophilized |
| Conservateur | No preservative |
| Type de produit | Peptide |
| Quantité | 50 μg |
| État réglementaire | RUO - research use only |
| Séquence | Derived from Amino Acids 887-902 of Human Maxi K+ a Protein |
