Synthetic Peptide
p53AIP1 Synthetic Peptide, PEP-0475, from Invitrogen.
The novel protein p53AIP, p53-regulated apoptosis-inducing protein 1, has been identified from the direct cloning of p53 binding sequences from human genomic DNA. The expression of p53AIP1 in mitochondria is induced by wild-type p53, which leads to apoptotic cell death through dissipation of mitochondrial Dym. Severe DNA damage causes the phosphorylation of p53 at Ser-46, p53AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53AIP1. P53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, thus plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53 dependent apoptosis to eliminate dangerous cells. In the opposite, p53AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser46 regulates the transcriptional activation of this apoptosis inducing gene.
| Marque | Invitrogen |
|---|---|
| Réf. B-LABO | BL-RE-176413 |
| Réf. fabricant | 15216689 |
| Gene ID (Entrez) | 63970 |
| Espèces | Human |
| Méthode de purification | purified |
| Numéro d’adhésion | Q9HCN2 |
| Nom usuel | Human p53AIP1 |
| Concentration | 200 μg/mL |
| Contenu et stockage | -20°C |
| Format | Liquid |
| Formule | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
| À utiliser avec (application) | Blocking Assay, Control |
| Symbole de gène(s) | TP53AIP1 |
| Lyophilisé | No |
| Conservateur | 0.02% sodium azide |
| Type de produit | Peptide |
| Quantité | 50 μg |
| État réglementaire | RUO - research use only |
| Tampon de stockage | PBS |
