Synthetic Peptide
Human alpha-ENaC (residues 20-42) Synthetic Peptide, PEP-088, from Invitrogen.
Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
| Marque | Invitrogen |
|---|---|
| Réf. B-LABO | BL-RE-176917 |
| Réf. fabricant | 11564740 |
| Gene ID (Entrez) | 6337 |
| Espèces | Human |
| Méthode de purification | purified |
| Numéro d’adhésion | P37088 |
| Nom usuel | Human ENaC alpha (aa 20-42) |
| Concentration | 0.5 mg/mL |
| Contenu et stockage | -20°C. Avoid freeze-thaw cycles. |
| Format | Lyophilized |
| Formule | peptide with no preservative |
| À utiliser avec (application) | Control |
| Symbole de gène(s) | SCNN1A |
| Lyophilisé | Lyophilized |
| Conservateur | No preservative |
| Type de produit | Peptide |
| Quantité | 50 μg |
| État réglementaire | RUO - research use only |
| Séquence | L(20) -M-K-G-N-K-R-E-E-Q-G-L-G-P-E-P-A-A-Q-Q-P-T(42)-C |
