Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.
- Numéro d’adhésion
- O15263
- Plage de dosage
- Lot-specific
- Sensibilité du dosage
- Lot-specific
- Conjugué
- Biotine
- Type de produit
- ELISA
- À utiliser avec (équipement)
- Lecteur de microplaques colorimétriques
- Identification génétique (Entrez)
- 1673
- Symbole de gène(s)
- DEFB4A
- Contenus des kits
- Capture Antibody, Detection Antibody, Protein Standard, HRP-conjugate
- Marqueur ou colorant
- HRP
- Quantité
- 10 x 96 tests
- État réglementaire
- RUO
- Conditions de stockage
- Refer to product documentation for component specific storage temperature.
- Cible
- beta-2 Defensin
- Heure du test
- 1 h 45 min
- Durée totale du dosage
- 24 h 30 min
