"/> Tocris Bioscience™ NX 5948 | B-LABO France

Tocris Bioscience™ NX 5948

Name: Tocris Bioscience™ NX 5948
Brand: Tocris Bioscience
SKU: 30279894
Price: 303.45 EUR
Availability: InStock

Réf. : BL-RE-177670Réf. fabricant : 30279894

303,45 € HT

Potent and selective BTK Degrader (PROTAC™)

Marque: Tocris Bioscience

NX 5948 is a potent and selective Bruton's tyrosine kinase (BTK) Degrader (PROTAC™) (DC50 = <1 nM; Dmax = 98%). Comprises a BTK binding moiety joined by a linker to cereblon (CRBN) ligand.

In vitro

, NX-5948 very potently, rapidly and completely degrades BTK in primary human B cells (DC50 = 0.034 nM). NX 5948 degrades BTK, inhibits tumor growth and increases survival in TMD8 xenograft mouse models of brain maligancy. Reduces inflammation and symptom severity in a mouse model of collagen-induced arthritis. NX 5948 is orally bioavailable and blood brain barrier penetrant.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.