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Tocris Bioscience™ PDEdelta ATTEC 12C

Name: Tocris Bioscience™ PDEdelta ATTEC 12C
Brand: Tocris Bioscience
SKU: 30245504
Price: 375.80 EUR
Availability: InStock

Réf. : BL-RE-177678Réf. fabricant : 30245504

375,80 € HT

PDEδ autophagy-tethering compound (ATTEC) Degrader

Marque: Tocris Bioscience

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.