ELISA
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
| Marque | Invitrogen |
|---|---|
| Réf. B-LABO | BL-RE-177846 |
| Réf. fabricant | 30245037 |
| Numéro d’adhésion | Q9UEF7 |
| Plage de dosage | 0.31 to 20 ng/mL |
| Sensibilité du dosage | 0.19 ng/mL |
| Conjugué | HRP |
| Type de produit | ELISA |
| Type d’échantillon | Plasma, Serum |
| À utiliser avec (équipement) | Colorimetric Microplate Reader |
| Identification génétique (Entrez) | 9365 |
| Symbole de gène(s) | KL |
| Coefficient de variation inter-dosage | <10 |
| Coefficient de variation intra-dosage | <10 |
| Contenus des kits | Micro ELISA Plate (Dismountable), Reference Standard, Concentrated Biotinylated Detection Ab(100x), Concentrated HRP Conjugate (100x), Reference Standard & Sample Diluent, Biotinylated Detection Ab Diluent, HRP Conjugate Diluent, Concentrated Wash Buffer(25x), Substrate Reagent, Stop Solution, Plate Sealer, Product Description, Certificate of Analysis |
| Marqueur ou colorant | Biotin |
| Quantité | 96 Tests |
| État réglementaire | RUO |
| Volume d’échantillon | Plasma: 100 μL, Serum: 100 μL |
| Conditions de stockage | Refer to product documentation for component specific storage temperature. |
| Cible | Klotho |
| Heure du test | 1 hr. 20 min. |
| Durée totale du dosage | 3 hr. 30 min. |
