Procollagen type I N-terminal propeptide (P1NP) is a specific marker of bone formation, reflecting the synthesis of type I collagen, which constitutes the major part of the bone matrix. P1NP is derived during the conversion of procollagen to collagen, produced by osteoblasts during bone formation. Its primary clinical application lies in the diagnosis and monitoring of metabolic bone diseases, particularly osteoporosis. In osteoporotic patients, P1NP levels can predict bone mineral density (BMD) responses to treatments like teriparatide and romosozumab. Low serum levels of P1NP are indicative of a high risk of BMD loss, providing a valuable tool for premenopausal women with systemic lupus erythematosus (SLE) and other conditions affecting bone health.
- Numéro d’adhésion
- P02452
- Plage de dosage
- 15.63 to 1000 pg/mL
- Sensibilité du dosage
- 9.38 pg/mL
- Conjugué
- HRP
- Type de produit
- ELISA
- Type d’échantillon
- Plasma, Serum
- À utiliser avec (équipement)
- Colorimetric Microplate Reader
- Identification génétique (Entrez)
- 1277
- Symbole de gène(s)
- COL1A1
- Coefficient de variation inter-dosage
- <10
- Coefficient de variation intra-dosage
- <10
- Contenus des kits
- Micro ELISA Plate (Dismountable), Reference Standard, Concentrated Biotinylated Detection Ab(100x), Concentrated HRP Conjugate (100x), Reference Standard & Sample Diluent, Biotinylated Detection Ab Diluent, HRP Conjugate Diluent, Concentrated Wash Buffer(25x), Substrate Reagent, Stop Solution, Plate Sealer, Product Description, Certificate of Analysis
- Marqueur ou colorant
- Biotin
- Quantité
- 96 Tests
- État réglementaire
- RUO
- Volume d’échantillon
- Plasma: 100 μL, Serum: 100 μL
- Conditions de stockage
- Refer to product documentation for component specific storage temperature.
- Cible
- Procollagen I N-Peptide
- Heure du test
- 1 hr. 20 min.
- Durée totale du dosage
- 3 hr. 30 min.
