KH-4-43 is a selective CUL4 inhibitor (Kd = 83 nM). KH-4-43 inhibits the ubiquitination of CK1α by CRL4CRBN in vitro. Treatment of cells with KH-4-43 causes accumulation of the E3 CRL4 substrate CDT1. KH-4-43 suppresses the growth of human tumor xenografts in mice.
- Nom chimique ou matériau
- 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one
- CAS
- 2813310-07-3
- Quantité
- 5 mg
- Cible
- Ubiquitin Ligase (E3) Inhibitors
- Formule moléculaire
- C19H10ClF3N2O4
- Pureté
- 0.98
