JP-2-196 is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM. By facilitating E3 ligase recruitment, JP-2-196 induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders.
- Nom chimique ou matériau
- 1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione hydrochloride
- Quantité
- 50 mg
- Cible
- Molecular Glues
- Formule moléculaire
- C15H18N2O3.HCl
- Pureté
- 0.95
