IBG3 is a very potent JQ1 -containing molecular glue Degrader of BET proteins BRD4 and BRD2 (DC50 values are 6.7 pM and 8.6 pM respectively). Induces proximity between BRD4 and DCAF16 to form a ternary complex (EC50 = 32 nM).
- Nom chimique ou matériau
- tert-Butyl 2-((S)-4-(4-((4'-((S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-[1,1'-biphenyl]-4-carboxamido)methyl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]dia
- Quantité
- 2 mg
- Cible
- Molecular Glues
- Formule moléculaire
- C54H57N9O5S2
