Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling
It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1)
Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.) Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)
Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.)
Induces autophagy in malignant glioma cells (Takeuchi et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-032789
Réf. fabricant
17130212
CAS
53123-88-9
Pourcentage de pureté
≥95%
Quantité
10 mg
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