Selective HIF-1 dimerization inhibitor
TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM) . Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells
in vitro
. Also reduces tubularization of hypoxic HUVECs.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-049088 |
| Réf. fabricant | 18757078 |
| Pureté | 95% |
| CAS | 1446322-66-2 |
| Contenu et stockage | Store at -20°C |
| Poids moléculaire | Observed M.W.: 2559.1 |
| Quantité | 1 mg |
| Forme structurelle | C<sub>111</sub>H<sub>188</sub>N<sub>42</sub>O<sub>24</sub>S<sub>2</sub> |
