Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione
S
-transferase omega 1 inhibitor. Orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-050223 |
| Réf. fabricant | 18713168 |
| Pureté | 98% |
| Poids moléculaire | 426.46 |
| Type de produit | CRID3 sodium salt |
| Quantité | 10 mg |
