Potent C5a receptor antagonist
PMX 53 is a potent C5a receptor antagonist (IC50 = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.
Negative Control also available.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-051613 |
| Réf. fabricant | 18729718 |
| Pureté | 0.95 |
| Poids moléculaire | 896.1 |
| Type de produit | PMX 53 |
| Quantité | 1 mg |
| Séquence | Ac-Phe-cyclo(Orn-Pro-dCha-Trp-Arg) |
