Selective blocker of inward-rectifier K+ channels
Tertiapin-Q is a high affinity blocker for inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin. Tertiapin-Q binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Tertiapin-Q improves heart rate and atrioventricular conduction in a mouse model of bradycardia. Derivative Tertiapin LQ (Cat. No. 4339) also available.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-054887 |
| Réf. fabricant | 18769086 |
| Pureté | 0.95 |
| Contenu et stockage | Store at -20°C |
| Poids moléculaire | 2452 |
| Type de produit | Tertiapin-Q |
| Quantité | 1 mg |
| Séquence | Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2 (Disulfide bridges: 3 - 14, 5 - 18) |
