TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels
GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity
in vivo
in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-054888 |
| Réf. fabricant | 18745727 |
| CAS | 1209500-46-8 |
| Quantité | 100 μg |
