Potent hNav1.4, rNav1.6 and rNav1.7 channel activator
OD1 is a potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-055948 |
| Réf. fabricant | 18757678 |
| Pureté | 95% |
| Contenu et stockage | Store at -20°C |
| Poids moléculaire | Observed M.W.: 7206.1 |
| Quantité | 10 μg |
| Forme structurelle | C<sub>308</sub>H<sub>466</sub>N<sub>90</sub>O<sub>95</sub>S<sub>8</sub> |
