Used for SDS-PAGE
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
| Marque | Abnova |
|---|---|
| Réf. B-LABO | BL-RE-056566 |
| Réf. fabricant | 16058096 |
| Concentration | 0.44 mg/mL |
| À utiliser avec (application) | SDS-PAGE |
| Formule | In 0.05M sodium acetate, 0.1M NaCl, pH 7.4 (1mM EDTA) |
| Identification génétique (Entrez) | 5328 |
| Poids moléculaire | 33kDa |
| Nom | PLAU (Human) Native Protein |
| Méthode de préparation | Native protein purified from human urine |
| Méthode de purification | Column chromatography |
| Quantité | 100 ug |
| Conditions de stockage | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| État réglementaire | RUO |
| Alias de gène | ATF/UPA/URK/UROKINASE/u-PA |
| Nom usuel | PLAU |
| Symbole de gène(s) | PLAU |
| Espèces | Human |
| Marqueur de protéine | None |
| Système d’expression | Native protein purified from human urine |
| Forme | Liquid |
| Pureté ou qualité | >98% by SDS-PAGE |
