KRas/SOS1 interaction inhibitor
SAH-SOS1A is a KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
Sold under license from Dana-Farber Cancer Institute
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-084228 |
| Réf. fabricant | 18788726 |
| CAS | 1652561-87-9 |
| Contenu et stockage | Store at -20°C |
| Formule | C<sub>100</sub>H<sub>159</sub>N<sub>27</sub>O<sub>28</sub> |
| Poids moléculaire | 2187.53 |
| Quantité | 500 μg |
| Séquence | RRFFGIXLTNXLKTEEGN (Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-7 and X-11 stapled together with a double bond) |
