Potent and selective PDGFR family inhibitor
AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-084267 |
| Réf. fabricant | 18720278 |
| Pureté | >99% |
| Poids moléculaire | 562.7 |
| Type de produit | AC 710 |
| Quantité | 10 mg |
