Cell permeable NFAT inhibitor
NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and
Nos2
mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels;
in vitro
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-085261 |
| Réf. fabricant | 18706509 |
| CAS | 592517-80-1 |
| Contenu et stockage | Store at -20°C |
| Poids moléculaire | Observed M.W.: 3573.15 |
| Quantité | 1 mg |
| Forme structurelle | C<sub>147</sub>H<sub>259</sub>N<sub>67</sub>O<sub>36</sub>S |
