Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2
Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties
in vivo
.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-085296 |
| Réf. fabricant | 18023802 |
| Pureté | 0.95 |
| Contenu et stockage | Store at -20°C |
| Quantité | 1 mg |
