Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
Caractéristiques techniques
| Marque | Invitrogen |
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| Réf. B-LABO | BL-RE-091184 |
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| Réf. fabricant | 18597864 |
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| Numéro d’adhésion | activin A; activin beta-A chain; EDF; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FRP; FSH-releasing protein; Inhba; Inhibin beta A chain; inhibin beta A subunit; inhibin beta-A; inhibin beta-subunit; inhibin subunit beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; unnamed protein product |
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| Plage de dosage | 0.5 to 100 pg/mL |
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| Sensibilité du dosage | 0.5 pg/mL |
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| Conjugué | Biotin |
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| Type de produit | ELISA |
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| Type d’échantillon | Serum |
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| À utiliser avec (équipement) | Colorimetric Microplate Reader |
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| Identification génétique (Entrez) | Q04998 |
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| Symbole de gène(s) | Inhba |
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| Coefficient de variation inter-dosage | <12% |
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| Coefficient de variation intra-dosage | <10% |
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| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
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| Marqueur ou colorant | HRP |
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| Quantité | 10 x 96 Tests |
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| État réglementaire | Research Use Only |
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| Volume d’échantillon | Serum, 50 µL; Supernatant, 50 µL; Plasma, 50 µL |
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| Conditions de stockage | 2°C to 8°C |
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| Cible | Activin A |
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| Heure du test | 1 hr 20 min |
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| Durée totale du dosage | 4 hr 45 min |
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