CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Caractéristiques techniques
| Marque | Invitrogen |
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| Réf. B-LABO | BL-RE-091192 |
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| Réf. fabricant | 18587824 |
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| Numéro d’adhésion | 4 1 BB; 41 BB; 4-1 BB; 4-1 BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1 BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1 BB; s4 1 BB; s4 1 BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1 BB; soluble 41 BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1 BB; T-cell antigen 4-1 BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 |
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| Plage de dosage | 1.5 to 300 ng/mL |
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| Sensibilité du dosage | 1.5 ng/mL |
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| Conjugué | Biotin |
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| Type de produit | ELISA |
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| Type d’échantillon | Plasma |
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| À utiliser avec (équipement) | Colorimetric Microplate Reader |
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| Symbole de gène(s) | TNFRSF9 |
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| Coefficient de variation inter-dosage | <12% |
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| Coefficient de variation intra-dosage | <10% |
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| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
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| Marqueur ou colorant | HRP |
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| Quantité | 10 x 96 Tests |
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| État réglementaire | Research Use Only |
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| Volume d’échantillon | Plasma, 50 µL; Supernatant, 50 µL; Serum, 50 µL |
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| Conditions de stockage | 2°C to 8°C |
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| Cible | 4-1 BB (CD137) |
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| Heure du test | 1 hr 20 min |
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| Durée totale du dosage | 4 hr 45 min |
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