Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Caractéristiques techniques
| Marque | Invitrogen |
|---|
| Réf. B-LABO | BL-RE-093365 |
|---|
| Réf. fabricant | 18567824 |
|---|
| Numéro d’adhésion | CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL6Q; Il6r; IL-6 R; IL-6 R 1; IL-6 R subunit alpha; IL6R1; IL-6 R-1; Il6ra; IL-6 RA; IL-6 R-alpha; IL6RQ; ILN; Interleukin; interleukin 6 receptor; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991 |
|---|
| Plage de dosage | 12 to 3,000 pg/mL |
|---|
| Sensibilité du dosage | 12 pg/mL |
|---|
| Conjugué | Biotin |
|---|
| Type de produit | ELISA |
|---|
| Type d’échantillon | Plasma |
|---|
| À utiliser avec (équipement) | Colorimetric Microplate Reader |
|---|
| Coefficient de variation inter-dosage | <12% |
|---|
| Coefficient de variation intra-dosage | <10% |
|---|
| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
|---|
| Marqueur ou colorant | HRP |
|---|
| Quantité | 10 x 96 Tests |
|---|
| État réglementaire | Research Use Only |
|---|
| Volume d’échantillon | Supernatant, 50 µL; Plasma, 50 µL; Serum, 50 µL |
|---|
| Conditions de stockage | 2°C to 8°C |
|---|
| Cible | IL-6 Receptor (CD126) |
|---|
| Heure du test | 1 hr 20 min |
|---|
| Durée totale du dosage | 4 hr 45 min |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
